RO314724 [112105-54-1]

TargetMol Chemicals

RO314724 [112105-54-1]

72

Chemical

Research Use Only

RO314724

C19H35N3O6

401.5

RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.

3 years

[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)(C(N[C@H](C(OCC)=O)C)=O)CC(C)C

-20°C

12352200