RO8994
T3517
CAS Number1309684-94-3
Product group Chemicals
Molecular Weight613.51
Overview
- SupplierTargetMol Chemicals
- Product NameRO8994
- Delivery Days Customer4
- CAS Number1309684-94-3
- Category SupplierChemical
- Chemical NameRO8994
- Molecular FormulaC31H31Cl2FN4O4
- Molecular Weight613.51
- Scientific DescriptionRO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
- Shelf life instruction3 years
- SMILESC(C(C)(C)C)[C@H]1[C@@]2([C@H]([C@H](C(NC3=C(OC)C=C(C(N)=O)C=C3)=O)N1)C4=C(F)C(Cl)=CC=C4)C=5C(NC2=O)=CC(Cl)=CC5
- Storage Instruction-20°
- UNSPSC12352200
References
- Zhang Z,et al. Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy. Bioorg Med Chem. 2014 Aug 1;22(15):4001-9.