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Romidepsin [128517-07-7]

R5749
LKT Laboratories
Estimated Purity≥98%
Product group Chemicals
€ 1.312,00
5 mg
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Overview

  • Supplier
    LKT Laboratories
  • Product Name
    Romidepsin [128517-07-7]
  • Delivery Days Customer
    7
  • Estimated Purity
    ≥98%
  • Format
    DMSO 10 mg/mL (18.49 mM); Water Insoluble; Ethanol Insoluble
  • Scientific Description
    HDAC inhibitor.; FK228, Istodax, Depsipeptide, FR901228, NSC630176
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Foss F, Coiffier B, Horwitz S, et al. Tolerability to romidepsin in patients with relapsed/refractory T-cell lymphoma. Biomark Res. 2014 Sep 8;2:16. PMID: 25279222. Satwani P, Bavishi S, Saha A, et al. Upregulation of NKG2D ligands in acute lymphoblastic leukemia and non-Hodgkin lymphoma cells by romidepsin and enhanced in vitro and in vivo natural killer cell cytotoxicity. Cytotherapy. 2014 May 20. [Epub ahead of print]. PMID: 24856896. Wei DG, Chiang V, Fyne E, et al. Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog. 2014 Apr 10;10(4):e1004071. PMID: 24722454. Karthik S, Sankar R, Varunkumar K, et al. Romidepsin induces cell cycle arrest, apoptosis, histone hyperacetylation and reduces matrix metalloproteinases 2 and 9 expression in bortezomib sensitized non-small cell lung cancer cells. Biomed Pharmacother. 2014 Apr;68(3):327-34. PMID: 24485799. Ueda H, Nakajima H, Hori Y, et al. FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo). 1994 Mar;47(3):301-10. PMID: 7513682.