ROR-gamma / RORC (RAR-related Orphan Receptor C)(RORC/2942), CF594 conjugate, 0.1mg/mL [26628-22-8]

Biotium

ROR-gamma / RORC (RAR-related Orphan Receptor C)(RORC/2942), CF594 conjugate, 0.1mg/mL

9

Research Use Only

Monoclonal

RORC/2942

0.1 mg/ml

Other Conjugate

RORC

RAR related orphan receptor C

IMD42; NR1F3; nuclear receptor ROR-gamma; nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan nuclear receptor variant 2; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; RORG; RZRG; RZR-GAMMA; TOR

Mouse

IgG2a

Nuclear receptor ROR-gamma

This MAb recognizes a protein of 63 kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR and ROR are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50% amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors, due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203