RORgamma/DHODH-IN-2

MedChem Express

RORgamma/DHODH-IN-2

9

Research Use Only

C22H16D2ClF4N5O2

497.87

RORgamma/DHODH-IN-2 (Compound 1311) is an orally active dual inhibitor of RORgamma/DHODH with IC50 values of 11.9 nM and 90 nM, respectively. RORgamma/DHODH-IN-2 exhibits antiviral activity by inhibiting the activity of SARS-CoV-2, HCMV, HAdV5, and MPXV, with IC50 values of 27 nM, 20 nM, 9.1 nM, and 1.8 nM, respectively[1].

ClC1=C(C(F)=CC=C1)C2=NOC(C3=C(N(N=C3)C([2H])(CC(C)(C)O)[2H])C(F)(F)F)=C2C4=NC=CC=N4

12352200