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ProductsBack/Roridin E [16891-85-3]
Chemical Structure
Chemical Structure
Chemical Structure

Roridin E [16891-85-3]

Research Use Only
AG-CN2-0176
AdipoGen Life Sciences
CAS Number16891-85-3
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight514.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Roridin E
  • Delivery Days Customer
    10
  • CAS Number
    16891-85-3
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C29H38O5
  • Molecular Weight
    514.6
  • Scientific Description
    Chemical. CAS: 16891-85-3. Formula: C29H38O5. MW: 514.6. Isolated from fungus Trichoderma sp. Mycotoxin. Implicated in human and animal toxicosis. Potent cytotoxic and antiproliferative agent against cancer cell lines. Potent antimalarial agent. Antifungal, antibiotic, phototoxic and cytostatic agent. Antiviral against arenavirus Junin (JUNV). - Mycotoxin. Implicated in human and animal toxicosis. Potent cytotoxic and antiproliferative agent against cancer cell lines. Potent antimalarial agent. Antifungal, antibiotic, phototoxic and cytostatic agent. Antiviral against arenavirus Junin (JUNV).
  • SMILES
    [H]C12[C@@]3([C@]4(C)[C@]5(CO5)[C@](C[C@H]4OC(/C=C\C=C\[C@](OCC/C(C)=C/C(OC3)=O)([H])C(O)C)=O)([H])O2)CCC(C)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Structure of the antibiotic Roridin E: P. Traxler, et al.; Helv. Chim. Acta 53, 2071 (1970)
  • Effects of macrocyclic trichothecene mycotoxins on the murine immune system: B.J. Hughes, et al.; Arch. Environ. Contam. Toxicol. 18, 388 (1989)
  • Antimalarial activity of macrocyclic trichothecenes isolated from the fungus Myrothecium verrucaria: M. Isaka, et al.; J. Nat. Prod. 62, 329 (1999)
  • Phytotoxicity and mammalian cytotoxicity of macrocyclic trichothecene mycotoxins from Myrothecium verrucaria: H.K. Abbas, et al.; Phytochem. 59, 309 (2002)
  • Evaluation of the antiviral activity against Junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia: C.C. Garcia, et al.; Planta Med. 68, 209 (2002)
  • 12'-Hydroxyl group remarkably reduces Roridin E cytotoxicity: T. Oda, et al.; Mycosciences 51, 317 (2010)
  • Isolation and characterization of roridin E: C.D. Ridge, et al.; MRC 55, 337 (2017)
  • Preparative separation and purification of trichothecene mycotoxins from the marine fungus Fusarium sp. LS68 by high-speed countercurrent chromatography in stepwise elution mode: Y. Liu, et al.; Mar. Drugs 16, 73 (2018)