Rosiglitazone-d3 [1132641-22-5]

MedChem Express

Rosiglitazone-d3 [1132641-22-5]

10

1132641-22-5

Research Use Only

C18H16D3N3O3S

360.45

Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARgamma agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARgamma1, PPARgamma2, and PPARgamma, respectively. Rosiglitazone binds to PPARgamma with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 microM) and an inhibitor of TRPM3[1][2][3][4].

O=C(N1)C(CC2=CC=C(OCCN(C3=NC=CC=C3)C([2H])([2H])[2H])C=C2)SC1=O

See Manual

12352200