Rp-8-Br-PET-cGMPS (sodium)

MedChem Express

Rp-8-Br-PET-cGMPS (sodium) [185246-32-6]

5

185246-32-6

Research Use Only

C18H14BrN5NaO6PS

562.27

Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 microM) and cGMP-induced activation of cyclic nucleotide-gated channels ( IC 50 =25 microM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 microM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

BrC1=NC2=C(NC3=NC(C4=CC=CC=C4)=CN3C2=O)N1[C@@](O[C@@](CO5)([H])[C@@]6([H])O[P@@]5(S[Na])=O)([H])[C@@H]6O.[R]

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