(RS)-4CPG

MedChem Express

(RS)-4CPG [7292-81-1]

9

7292-81-1

Research Use Only

C9H9NO4

195.17

(RS)-4CPG ((RS)-4-Carboxyphenylglycine) is a type I metabotropic glutamate receptor antagonist with activity in blocking LTP induction. In mice lacking IP3R1, (RS)-4CPG (500microM) nearly blocked long-term potentiation (LTP) induced by type I metabotropic glutamate receptor activation, with LTP of 117.6+/-1.7% (n = 8) in IP3R1(-/-) mice and 116.9+/-1.8% (n = 5) in IP3R1(+/+) mice.

O=C(O)C(N)C1=CC=C(C(O)=O)C=C1

12352200