(R,S,R)-ML334

MedChem Express

(R,S,R)-ML334

14

Research Use Only

98.57

C26H26N2O5

446.50

(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K d of 1 microM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity [1] [2] .

O=C([C@H]1[C@@H](C(N2[C@@H](CN(C(C3=C4C=CC=C3)=O)C4=O)C5=C(C=CC=C5)CC2)=O)CCCC1)O

-20°C,2°C to 8°C

12352200