RSV L-protein-IN-5

MedChem Express

RSV L-protein-IN-5

14

Research Use Only

C31H36N6O4

556.66

RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus (RSV) (EC50=0.1 microM). RSV L-protein-IN-5 inhibits Polymerase (IC50=0.66 microM), and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 microM, HEp-2), also exhibits activity and lowers virus titers in mouse models of RSV infection[1].

O=C1C2=C(C(C)(C)C(N1CCCNCCC3=CC=C(C(OC)=C3)OC)=O)C=C(N)C4=C2NC(C5=CC=CC(C)=N5)=N4

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