rTRD01 [1332175-56-0]

TargetMol Chemicals

rTRD01 [1332175-56-0]

16

Chemical

Research Use Only

rTRD01

C18H21FN4O2

344.38

rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 microM for TDP-43 102-269. The compound can partially disrupt the interaction between TDP-43 and the hexanucleotide RNA repeat associated with the c9orf72 gene, implicated in certain neurodegenerative diseases. rTRD01 holds potential for use in neurodegenerative disease research [1].

3 years

O=C(N)C=1N=C(C=NC1)N2CCCC(CO)(CC3=CC=C(F)C=C3)C2

-20°C

12352200