RUNX1T1 Polyclonal Antibody

Reddot Biotech

RUNX1T1 Polyclonal Antibody

5

Western Blot

Research Use Only

1 mg/ml

Unconjugated

RUNX1T1

RUNX1 partner transcriptional co-repressor 1

acute myelogenous leukemia 1 translocation 1, cyclin-D related; AML1-MTG8; AML1T1; CBFA2T1; CDR; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; eight twenty one protein; ETO; MTG8; myeloid translocation gene on 8q22; protein CBFA2T1; runt related transcription factor 1; translocated to, 1 (cyclin D related); RUNX1 translocation partner 1; zinc finger MYND domain-containing protein 2; ZMYND2

Rabbit

IgG

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5-region of the runt-related transcription factor 1 gene fused to the 3-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Human

-20°C

12352203