WB analysis of rat kidney tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX85246 RWDD3 antibody. Working concentration : 1 microg/ml
WB analysis of rat kidney tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX85246 RWDD3 antibody. Working concentration : 1 microg/ml
RWDD3 antibody
GTX85246
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetRWDD3
Overview
- SupplierGeneTex
- Product NameRWDD3 antibody
- Delivery Days Customer9
- Antibody SpecificityThis antibody is specific for RWDD3 C-Terminus
- Application Supplier NoteWB: 1 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID25950
- Target nameRWDD3
- Target descriptionRWD domain containing 3
- Target synonymsRSUME; RWD domain-containing protein 3; RWD domain-containing sumoylation enhancer; RWD-containing sumoylation enhancer
- HostRabbit
- IsotypeIgG
- Protein IDQ9Y3V2
- Protein NameRWD domain-containing protein 3
- Scientific DescriptionRWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203