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ProductsBack/(S)-CR8 [1084893-56-0]
Chemical Structure
Chemical Structure
Chemical Structure

(S)-CR8 [1084893-56-0]

Research Use Only
AG-CR1-0040
AdipoGen Life Sciences
CAS Number1084893-56-0
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight431.5
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (S)-CR8 [1084893-56-0]
  • Delivery Days Customer
    10
  • CAS Number
    1084893-56-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C24H29N7O
  • Molecular Weight
    431.5
  • Scientific Description
    Chemical. CAS: 1084893-56-0. Formula: C24H29N7O. MW: 431.5. Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Glycogen synthase kinase (GSK-3alpha/beta) inhibitor. - Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor [1]. Apoptosis inducer [1, 2]. Glycogen synthase kinase (GSK-3alpha/beta) inhibitor [1].
  • SMILES
    CC[C@@H](CO)NC1=NC2=C(N=CN2C(C)C)C(NCC2=CC=C(C=C2)C2=NC=CC=C2)=N1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases: K. Bettayeb, et al.; Oncogene 27, 5797 (2008)
  • CDK inhibitors roscovitine and CR8 trigger Mcl-1 down-regulation and apoptotic cell death in neuroblastoma cells: K. Bettayeb, et al.; Genes Cancer 1, 369 (2010)
  • CDK inhibitors R-roscovitine and S-CR8 effectively block renal and hepatic cystogenesis in an orthologous model of ADPKD: N.O. Bukanov, et al.; Cell Cycle 11, 4040 (2012)
  • Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice: H. Sallam, et al.; BMC Pharmacol. Toxicol. 14, 50 (2013)
  • Inhibition of NF-kappaB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes prosurvival stimuli to induce apoptosis in chronic lymphocytic leukemia cells: E. Cosimo, et al.; Clin. Cancer Res. 19, 2393 (2013)