(S)-GSK-F1

MedChem Express

(S)-GSK-F1

5

C27H18F5N5O4S

603.52

(S)-GSK-F1 (Compound 28) is an inhibitor for type III phosphatidylinositol 4-kinase alpha ( PI4KIIIalpha ). (S)-GSK-F1 inhibits PI4Kalpha, PI4Kbeta, PI4Kgamma, PI3Kalpha, PI3Kbeta and PI3Kdelta with pIC 50 of 8.3, 6.0, 5.6, 5.6, 5.1 and 5.6, respectively. (S)-GSK-F1 exhibits anti-hepatitis C virus (HCV) activity through inhibition of HCV replication. (S)-GSK-F1 exhibits moderate pharmacokinetic characters in rat model [1] .

O=C1C2=C(N=C(N1C3=CC=CC=C3C(F)(F)F)N)C=CC(C4=CC(S(=O)(NC5=CC=C(C=C5F)F)=O)=C(OC)N=C4)=C2

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