S-methyl DM1 [912569-84-7]

MedChem Express

S-methyl DM1 [912569-84-7]

10

912569-84-7

Research Use Only

99.58

C36H50ClN3O10S

752.31

S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 microM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2].

C[C@]1([C@@](CC(N(C2=CC3=CC(OC)=C2Cl)C)=O)([H])OC([C@H](C)N(C)C(CCSC)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C3)([H])OC)(N4)O)C)O1

-20°C

41116133