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(S)-PFI-2 (hydrochloride)

HY-110196
MedChem Express
CAS Number1627607-88-8
DownloadMSDS
Product group Chemicals
Molecular Weight535.98
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Overview

  • Supplier
    MedChem Express
  • Product Name
    (S)-PFI-2 (hydrochloride) [1627607-88-8]
  • Delivery Days Customer
    5
  • CAS Number
    1627607-88-8
  • Certification
    Research Use Only
  • Molecular Formula
    C23H26ClF4N3O3S
  • Molecular Weight
    535.98
  • Scientific Description
    (S)-PFI-2 hydrochloride is an inhibitor of lysine methyltransferase SETD7 and is approximately 500-fold more active than its enantiomer (R)-PFI-2. (R)-PFI-2 is a cofactor-dependent and substrate-competitive inhibitor. (R)-PFI-2 can occupy the substrate peptide binding groove of SETD7 (including the catalytic lysine binding channel) and interact with the cofactor The donor methyl group is in direct contact. However, (S)-PFI-2 was not observed to have the same interaction as (R)-PFI-2 [1] [2] .
  • SMILES
    O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.Cl
  • UNSPSC
    12352200