(S)-Ro 32-0432 (free base)

MedChem Express

(S)-Ro 32-0432 (free base)

14

Research Use Only

C28H28N4O2

452.55

(S)-Ro 32-0432 free base is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC 50 values of (S)-Ro 32-0432 free base for PKCalpha , PKCbetaI , PKCbetaII , PKCgamma and PKCepsilon are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S)-Ro 32-0432 free base is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S)-Ro 32-0432 free base prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research [1] [2] .

O=C(C(C1=C(C[C@@H](CN(C)C)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O

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