(S)-Sunvozertinib

MedChem Express

(S)-Sunvozertinib [2370013-49-1]

10

2370013-49-1

Research Use Only

99.14

C29H35ClFN7O3

584.08

(S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK[1].

C=CC(NC1=C(N2C[C@H](CC2)N(C)C)C=C(C(NC3=NC=CC(NC4=C(C=C(C(Cl)=C4)F)C(C)(O)C)=N3)=C1)OC)=O

-20°C

12352200