S1RA

MedChem Express

S1RA [878141-96-9]

10

878141-96-9

Research Use Only

99.43

C20H23N3O2

337.42

S1RA (E-52862) is a highly selective sigma1 receptor (sigma1R) antagonist with Kis of 17 nM and 23.5 nM for human sigma1R and guinea pig sigma1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT2B receptor (Ki= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice[1][2].

CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3

-20°C,2°C to 8°C

12352200