More than 130 suppliers
ISO certified
In-house tech support
we Connect you
Bio-Connect
ProductsBack/Salinosporamide A

Salinosporamide A

BS-75213C
Bioss Antibodies
Estimated Purity>95%
Product group Chemicals
Sign in to order and to see your custom pricing.
Large volume orders?
Order with a bulk request
More than 130 suppliers
ISO certified
In-house tech support

Overview

  • Supplier
    Bioss Antibodies
  • Product Name
    Salinosporamide A [437742-34-2]
  • Delivery Days Customer
    16
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Scientific Description
    Potent, irreversible inhibitor of all the 3 proteolytic activities of the mammalian 20S proteasome. beta5 subunit: chymotrypsin-like (EC50 = 3.5nM) beta2 subunit: trypsin-like (EC50 = 28nM) beta1 subunit: caspase-like or peptidyl-glutamyl peptide-hydrolyzing (PGPH) (EC50 = 430nM) Potent anticancer compound. Triggers apoptosis, with distinct proteasome activity and mechanism of action compared to bortezomib (Velcade) (Prod. No. bs-75509C). Most potent suppressor of NF-kappaB activation, compared with bortezomib, MG-132 (Prod. No. bs-75297C), N-acetyl-leucyl-leucyl-norleucinal (ALLN) and lactacystin (Prod. No. bs-75086C). Inhibitor of TNF-alpha, IL-1, IL-6, ICAM-1 and VEGF synthesis. Displays a longer inhibition duration than bortezomib. Potent antileukemic activity against bortezomib-resistant leukemia cells.
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000