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ProductsBack/SANT-2 [329196-48-7]
Chemical Structure
Chemical Structure
Chemical Structure

SANT-2 [329196-48-7]

Research Use Only
AG-CR1-3514
AdipoGen Life Sciences
CAS Number329196-48-7
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Product group Chemicals
Estimated Purity>95% (NMR)
Molecular Weight480
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SANT-2 [329196-48-7]
  • Delivery Days Customer
    10
  • CAS Number
    329196-48-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (NMR)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C26H26ClN3O4
  • Molecular Weight
    480
  • Scientific Description
    Chemical. CAS: 329196-48-7. Formula: C26H26ClN3O4. MW: 480. Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker. - Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.
  • SMILES
    CCOC1=CC(=CC(OCC)=C1OCC)C(=O)NC1=CC(C2=NC3=C(N2)C=CC=C3)=C(Cl)C=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002)
  • Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review)
  • Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009)
  • Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009)
  • Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. Büttner, et al.; Bioorg. Med. Chem. 17, 4943 (2009)