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SARM1 antibody

Name: SARM1 antibody
SKU: GTX131411_G10
Availability: BackOrder

GTX131411

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

ReactivityDrosophila, Human, Mouse

TargetSARM1

Overview

Supplier
GeneTex
Product Name
SARM1 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.4 mg/ml
Conjugate
Unconjugated
Gene ID23098
Target name
SARM1
Target description
sterile alpha and TIR motif containing 1
Target synonyms
HsTIR, MyD88-5, SAMD2, SARM, hSARM1, NAD(+) hydrolase SARM1, NADP(+) hydrolase SARM1, NADase SARM1, SAM domain-containing protein 2, sterile alpha and Armadillo repeat protein, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila, sterile alpha and TIR motif-containing protein 1, sterile alpha motif domain-containing protein 2, tir-1 homolog
Host
Rabbit
Isotype
IgG
Protein IDQ6SZW1
Protein Name
NAD(+) hydrolase SARM1
Scientific Description
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Reactivity
Drosophila, Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Jin L, Zhang J, Hua X, et al. Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling. Cell Death Dis. 2022,13(9):759. doi: 10.1038/s41419-022-05202-z
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Xiang L, Wu Q, Sun H, et al. SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice. Cell Death Dis. 2022,13(7):638. doi: 10.1038/s41419-022-05083-2
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Sur M, Dey P, Sarkar A, et al. Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity. Cell Death Discov. 2018,4:114. doi: 10.1038/s41420-018-0119-5
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