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SARM1 antibody

Name: SARM1 antibody
SKU: GTX131411_G10
Availability: BackOrder

GTX131411

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Product group Antibodies

TargetSARM1

Overview

Supplier
GeneTex
Product Name
SARM1 antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.4 mg/ml
Conjugate
Unconjugated
Gene ID23098
Target name
SARM1
Target description
sterile alpha and TIR motif containing 1
Target synonyms
hSARM1; HsTIR; MyD88-5; NAD(+) hydrolase SARM1; NADase SARM1; NADP(+) hydrolase SARM1; SAM domain-containing protein 2; SAMD2; SARM; sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; sterile alpha and TIR motif-containing protein 1; sterile alpha motif domain-containing protein 2; tir-1 homolog
Host
Rabbit
Isotype
IgG
Protein IDQ6SZW1
Protein Name
Sterile alpha and TIR motif-containing protein 1
Scientific Description
Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Astrocytic SARM1 promotes neuroinflammation and axonal demyelination in experimental autoimmune encephalomyelitis through inhibiting GDNF signaling.
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SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice. Xiang L et al., 2022 Jul 22, Cell Death Dis
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Sarm1 induction and accompanying inflammatory response mediates age-dependent susceptibility to rotenone-induced neurotoxicity. Sur M et al., 2018, Cell Death Discov
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