SARS-CoV-2-IN-11

MedChem Express

SARS-CoV-2-IN-11 [2722635-28-9]

10

2722635-28-9

Research Use Only

C27H38F2N3NaO8S

625.66

SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease ( 3CLpro ) with an IC 50 and EC 50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease ( 3CLpro ), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals [1] .

O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O

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