SARS-CoV-2 Mpro-IN-5

MedChem Express

SARS-CoV-2 Mpro-IN-5

10

Research Use Only

C34H43FN4O7

638.73

SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease ( M Pro ) and Cathepsin L ( CatL ), with IC 50 s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC 50 value of 14.7 nM [1] .

O=C([C@H](NC(OC(C)(C)C)=O)CC1=CC=C(F)C=C1)N[C@H](C(N[C@@H](C[C@@H]2CCNC2=O)/C=C/C(OCC)=O)=O)CC3=CC=CC=C3

12352200