SARS-CoV-IN-6

MedChem Express

SARS-CoV-IN-6

9

Research Use Only

C25H29N5O3

447.53

SARS-CoV-IN-6 (Compound 17) is an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp , with an IC 50 value of 7.8 microM against SARS-CoV-2 RdRp. SARS-CoV-IN-6 reduces cytopathic effects in cells infected with SARS-CoV-1 and SARS-CoV-2 replicon-based single-round infectious particles (SRIPs), and inhibits SARS-CoV N protein expression, with EC 50 values of 0.12 microM for SARS-CoV-1 replicon-based SRIPs and 1.47 microM for SARS-CoV-2 replicon-based SRIPs [1] .

CN1C(N(C)C=C(CNC2=CC=C3N(C[C@H]4C[C@@H]3CN(CC5=CC=CC=C5)C4)C2=O)C1=O)=O

12352200