SARS-CoV-IN-6

Biorbyt

SARS-CoV-IN-6

10

Research Use Only

98.00%

C25H29N5O3

447.53

SARS-CoV-IN-6 (Compound 17) acts as an inhibitor of SARS-CoV-1 and SARS-CoV-2 RdRp, demonstrating an IC50 value of 7.8 microM against SARS-CoV-2 RdRp. This compound reduces the cytopathic effects of single-round infectious particles (SRIP) infected with SARS-CoV-1 and SARS-CoV-2 replicons and inhibits the expression of SARS-CoVN proteins. The EC50 values for SRIP based on SARS-CoV-1 and SARS-CoV-2 replicons are 0.12 microM and 1.47 microM, respectively.

C(N1C[C@@]2(C=3N(C[C@@](C2)(C1)[H])C(=O)C(NCC=4C(=O)N(C)C(=O)N(C)C4)=CC3)[H])C5=CC=CC=C5

-20°C

12352200