SATB1 antibody, PAb
ORB66709
Overview
- SupplierBiorbyt
- Product NameSATB1 antibody, PAb
- Delivery Days Customer16
- ApplicationsWestern Blot
- Applications SupplierWB:1:1000-1:5000 WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- HostRabbit
- IsotypeIgG
- Scientific DescriptionRabbit polyclonal to SATB1.Special AT-rich sequence-binding protein 1 (SATB1) is a chromatin organizer and transcription factorthat integrates chromatin architecture with gene regulation. SATB1 binds to nuclear matrix/scaffoldassociatingAT-rich DNA sequences (MARs/SARs). It has been shown that SATB1 interacts withpromyelocytic leukemia protein (PML), and that SATB1 and PML function as a regulatory complexthat controls transcription by restructuring the dynamic chromatin-loop architecture. SATB1 isimplicated as a key regulator of the differentiation and activation of T cells. In cancer, SATB1 hasbeen shown to reprogram chromatin organization and the transcription profiles of breast tumors topromote growth and metastasis.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells. Eleftheriadis T et al., 2013 Dec, Hum ImmunolRead more