SB-1578 citrate

TargetMol Chemicals

SB-1578 citrate

79

1262279-15-1

Chemical

SB-1578 citrate

C32H38N4O11

654.67

SB-1578 citrate is a novel, orally bioavailable JAK2 inhibitor with specificity for JAK2 within the JAK family and also potent activity against FLT3 and c-Fms. SB1578 blocks the activation of these kinases and their downstream signaling in pertinent cells, leading to inhibition of pathological cellular responses. The biochemical and cellular activities of SB1578 translate into its high efficacy in two rodent models of arthritis.

3 years

-20°

12352200