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SB-218078

SB-218078

T16848
TargetMol Chemicals
CAS Number135897-06-2
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Product group Chemicals
Molecular Weight393.39
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SB-218078
  • Delivery Days Customer
    65
  • CAS Number
    135897-06-2
  • Category Supplier
    Chemical
  • Chemical Name
    SB-218078
  • Molecular Formula
    C24H15N3O3
  • Molecular Weight
    393.39
  • Scientific Description
    SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM).
  • Shelf life instruction
    3 years
  • SMILES
    O=C1C=2C3=C4C5=C(C2C(=O)N1)C=6C(N5C7OC(N4C=8C3=CC=CC8)CC7)=CC=CC6
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Murga M, et al. Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors. Nat Struct Mol Biol. 2011 Nov 27;18(12):1331-1335.
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