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SB-237376 (free base)

HY-108163
MedChem Express
Molecular Weight387.43
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    SB-237376 (free base)
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Molecular Formula
    C20H25N3O5
  • Molecular Weight
    387.43
  • Scientific Description
    SB-237376 (free base) is a potassium and calcium channel blocker. SB-237376 (free base) can inhibit the rapidly activating delayed rectifier potassium current I(Kr) ( IC 50 is 0.42 microM), and at high concentrations, it blocks the L-type calcium current I(Ca,L). In the rabbit ventricular model, SB-237376 (free base) can induce early afterdepolarizations (EADs) at a concentration of 3 microM. Compared to other IKr inhibitors such as dl-sotalol, SB-237376 has a lower proarrhythmic risk. SB-237376 (free base) holds potential for research in the field of arrhythmia-related diseases [1] .
  • SMILES
    O=C(NCCCNCCC1=CC=C(OC)C(OC)=C1)C2=CC=C([N+]([O-])=O)C=C2
  • UNSPSC
    12352200