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SB-267268

SB-267268

T16851
TargetMol Chemicals
CAS Number205678-26-8
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Product group Chemicals
Molecular Weight451.44
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SB-267268
  • Delivery Days Customer
    79
  • CAS Number
    205678-26-8
  • Category Supplier
    Chemical
  • Chemical Name
    SB-267268
  • Molecular Formula
    C22H24F3N3O4
  • Molecular Weight
    451.44
  • Scientific Description
    SB-267268 inhibits human and mouse alfavbèta3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human alfavbèta3, monkey alfavbèta3 and human alfavbèta5, respectively).
  • Shelf life instruction
    3 years
  • SMILES
    C(C(F)(F)F)N1CC=2C(C[C@@H](CC(O)=O)C1=O)=CC=C(OCCCNC3=CC=CC=N3)C2
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Wilkinson-Berka JL, et al. SB-267268, a nonpeptidic antagonist of alpha(v)beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1600-5.
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