SB-277011 hydrochloride

TargetMol Chemicals

SB-277011 hydrochloride

14

215804-67-4

Chemical

SB-277011 hydrochloride

C28H31ClN4O

475.03

SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally active, dopamine D3 receptor (D3R) antagonist that crosses the blood-brain barrier with Ki values of 10.7 nM and 11.2 nM for rodent and human D3R, respectively. 277011 hydrochloride is 80-100 times more selective for D3 receptors than other dopamine receptors, acting on D3 receptors (pKi:8.0), D2 receptors (pKi:6.0), 5-HT1B receptors (pKi<5.2) and 5-HT1D receptors (pKi:5.9).

3 years

Cl.O=C(N[C@H]1CC[C@H](CCN2CCc3cc(ccc3C2)C#N)CC1)c1ccnc2ccccc12

-20°

12352200