SB-284851-BT [219769-23-0]

TargetMol Chemicals

SB-284851-BT [219769-23-0]

72

Chemical

Research Use Only

SB-284851-BT

C26H26FN5O

443.52

SB-284851-BT is a chemical compound that serves as an inhibitor of BRD4, p38alpha, and BRDT, exhibiting varying degrees of affinity and inhibition for each. Specifically, it inhibits BRD4-BD1 with an IC50 value of 1.7 microM, p38alpha with a Kd of 0.47 nM, BRDT (1) with an IC50 value of 18 microM, and BRD4 (1) with an IC50 value of 3.7 microM. By targeting p38alpha, SB-284851-BT effectively reduces IL-8 production and, through inhibiting BRD4, down-regulates both the c-Myc and NF-kappaB gene pathways, crucial in cancer pathways. Additionally, SB-284851-BT is designed to combine with the bromine domain and extra terminal (BET) proteins.

3 years

O(C=1N=C(C2=C(N=CN2C3CCNCC3)C4=CC=C(F)C=C4)C=CN1)C5=CC(C)=CC(C)=C5

-20°C

12352200