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SB-657510

SB-657510

T12848
TargetMol Chemicals
CAS Number474960-44-6
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Product group Chemicals
Molecular Weight505.81
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SB-657510
  • Delivery Days Customer
    4
  • CAS Number
    474960-44-6
  • Category Supplier
    Chemical
  • Chemical Name
    SB-657510
  • Molecular Formula
    C19H22BrClN2O5S
  • Molecular Weight
    505.81
  • Scientific Description
    SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.
  • Shelf life instruction
    3 years
  • SMILES
    S(NC1=CC(O[C@@H]2CCN(C)C2)=C(Cl)C=C1)(=O)(=O)C3=CC(OC)=C(OC)C=C3Br
  • Storage Instruction
    -20°
  • UNSPSC
    12352200

References

  • Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013;21(4):277-283.
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