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ProductsBack/SB202190 [152121-30-7]
Chemical Structure
Chemical Structure
Chemical Structure

SB202190 [152121-30-7]

Research Use Only
AG-CR1-0028
AdipoGen Life Sciences
CAS Number152121-30-7
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight331.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SB202190 [152121-30-7]
  • Delivery Days Customer
    10
  • CAS Number
    152121-30-7
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Hazard Information
    Warning
  • Molecular Formula
    C20H14FN3O
  • Molecular Weight
    331.3
  • Scientific Description
    Chemical. CAS: 152121-30-7. Formula: C20H14FN3O. MW: 331.3. Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Autophagic vacuole inducer - Potent and cell permeable p38 MAP kinase inhibitor [1, 2]. Apoptosis inducer [3]. Inhibits p38alpha and beta, but not gamma and delta isoforms [4, 5]. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators [6]. JNK activator [7]. Autophagic vacuole inducer [8]
  • SMILES
    OC1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis: J.C. Lee, et al.; Nature 372, 739 (1994)
  • SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes: C.L Manthey, et al.; J. Leukoc. Biol. 64, 409 (1998)
  • Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase: S. Nemoto, et al.; J. Biol. Chem. 273, 16415 (1998)
  • Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta): Y. Jiang, et al.; J. Biol. Chem. 271, 17920 (1996)
  • The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase: K.P. Wilson, et al.; Chem. Biol. 4, 423 (1997)
  • A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase: T. Fox, et al.; Protein Sci. 7, 2249 (1998)
  • Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism: H. Muniyappa & K.C. Das; Cell. Signal. 20, 675 (2008)
  • SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition: MB. Menon, et al.; PLos One 6, e23054 (2011)