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ProductsBack/SB203580 [152121-47-6]
Chemical Structure
Chemical Structure
Chemical Structure

SB203580 [152121-47-6]

Research Use Only
AG-CR1-0030
AdipoGen Life Sciences
CAS Number152121-47-6
DownloadMSDS
Product group Chemicals
Estimated Purity>99%
Molecular Weight377.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SB203580 [152121-47-6]
  • Delivery Days Customer
    10
  • CAS Number
    152121-47-6
  • Certification
    Research Use Only
  • Estimated Purity
    >99%
  • Hazard Information
    Danger
  • Molecular Formula
    C21H16FN3OS
  • Molecular Weight
    377.4
  • Scientific Description
    Cell permeable, specific p38 MAP kinase inhibitor [1, 2, 5]. Binds to the ATP binding site of p38 MAP kinase [3]. T cell proliferation inhibitor [4]. IL-2 production inhibitor [4]. SAPK/JNK inhibitor [5]. COX-1 and -2 inhibitor [6]. Raf-1 activator [7, 8]. Apoptosis enhancer [9]. Antiproliferative [10]. PDK1 inhibitor [10]. Anti-inflammatory [11]. Review [12]. Enhances cardiomyogenesis of human embryonic stem cells (hESCs) [13]. - Chemical. CAS: 152121-47-6. Formula: C21H16FN3OS. MW: 377.4. Cell permeable, specific p38 MAP kinase inhibitor. Binds to the ATP binding site of p38 MAP kinase. T cell proliferation inhibitor. IL-2 production inhibitor. SAPK/JNK inhibitor. COX-1 and -2 inhibitor. Raf-1 activator. Apoptosis enhancer. Antiproliferative. PDK1 inhibitor. Anti-inflammatory. Review. Enhances cardiomyogenesis of human embryonic stem cells (hESCs).
  • SMILES
    C[S+]([O-])C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=NC=C1)C1=CC=C(F)C=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1: A. Cuenda, et al.; FEBS Lett. 364, 229 (1995)
  • Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase: T.F. Gallagher, et al.; Bioorg. Med. Chem. 5, 49 (1997)
  • Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site: P.R. Young, et al.; J. Biol. Chem. 272, 12116 (1997)
  • A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production: S.G. Ward, et al.; Biochem. Soc. Trans. 25, 304S (1997)
  • The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs): A. Clerk & P.H. Sugden; FEBS Lett. 426, 93 (1998)
  • Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase: A.G. Börsch-Haubold, et al.; J. Biol. Chem. 273, 28766 (1998)
  • Raf-1 is activated by the p38 mitogen-activated protein kinase inhibitor, SB203580: A. Kalmes, et al.; FEBS Lett. 444, 71 (1999)
  • Effect of SB 203580 on the activity of c-Raf in vitro and in vivo: C.A. Hall-Jackson, et al.; Oncogene 18, 2047 (1999)
  • SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils: H. Kankaanranta, et al.; J. Pharmacol. Exp. Ther. 290, 621 (1999)
  • The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mit: F.V. Lali, et al.; J. Biol. Chem. 275, 7395 (2000)