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ProductsBack/SB415286 [264218-23-7]
Chemical Structure
Chemical Structure
Chemical Structure

SB415286 [264218-23-7]

Research Use Only
AG-CR1-3658
AdipoGen Life Sciences
CAS Number264218-23-7
DownloadMSDS
Product group Chemicals
Estimated Purity>97%
Molecular Weight359.7
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    SB415286 [264218-23-7]
  • Delivery Days Customer
    10
  • CAS Number
    264218-23-7
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Hazard Information
    Warning
  • Molecular Formula
    C16H10ClN3O5
  • Molecular Weight
    359.7
  • Scientific Description
    Chemical. CAS: 264218-23-7. Formula: C16H10ClN3O5. MW: 359.7. Synthetic. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta). DYRK1A inhibitor (IC50=0.9microM). Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription. Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. Anticancer agent with antiproliferative activity. Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation. - Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta). DYRK1A inhibitor (IC50=0.9microM). Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription. Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. Anticancer agent with antiproliferative activity. Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.
  • SMILES
    ClC1=CC(NC2=C(C3=C([N+]([O-])=O)C=CC=C3)C(NC2=O)=O)=CC=C1O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

References

  • Selective small molecule inhibitors or glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription: M.P. Coghlan, et al.; Chem. & Biol. 7, 793 (2000)
  • Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurons from death: D.A.E. Cross, et al.; J. Neurochem. 77, 94 (2001)
  • Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase: K. MacAulay, et al.; Eur. J. Biochem. 270, 3829 (2003)
  • GSK3 inhibitors: development and therapeutic potential: P. Cohen & M. Goedert; Nat. Rev. Drug Discov. 3, 479 (2004)
  • Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta: B.J.R. Whittle, et al.; Br. J. Pharmacol. 147, 575 (2006)
  • The selectivity of protein kinase inhibitors: a further update: J. Bain, et al.; Biochem. J. 408, 297 (2007)
  • Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS: J. Dill, et al.; J. Neurosci. 28, 8914 (2008)
  • A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286: J.G. Pizarro, et al.; J. Cell. Mol. Med. 13, 3906 (2009)