SB525334

Biorbyt

SB525334 [356559-20-1]

16

356559-20-1

Research Use Only

C21H21N5

343.42

SB525334 is a potent and selective inhibitor of TGFbeta receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.

N1C2C(=CC(C3NC(C(C)(C)C)=NC=3C3=NC(C)=CC=C3)=CC=2)N=CC=1

12352200