SBI-810

MedChem Express

SBI-810

5

Research Use Only

SBI-810 is a functionally selected beta-arrestin-biased neurotensin receptor 1 ( NTSR1 ) allosteric modulator. SBI-810 modulates NTSR1 G protein signaling in a G protein-specific manner in the presence of the endogenous ligand, neurotensin (NT). SBI-810 fully antagonizes NT-induced activation of Gq, partially antagonizes NT-induced activation of Gi1 and is permissive of NTSR1 activation of GoA and G12 [1] [2] .

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