SCH-42354

MedChem Express

SCH-42354

10

Research Use Only

C16H23NO3S2

341.49

SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC 50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity [1] [2] .

CSCC[C@@H](C(O)=O)NC([C@@H](CS)CC1=C(C=CC=C1)C)=O

12352200