SCH 900229

MedChem Express

SCH 900229

9

Research Use Only

C21H21ClF2O6S2

506.97

SCH 900229 is a potent gamma-secretase inhibitor with selective activity against PS1. The Abeta40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Abeta. SCH 900229 has shown good Abeta-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimers disease[1].

O=S([C@]12C3=C(F)C=CC(F)=C3OC[C@@]1([H])[C@@H](OCC2)CCS(C)(=O)=O)(C4=CC=C(C=C4)Cl)=O

12352200