Scio-323

MedChem Express

Scio-323

9

Research Use Only

C27H30FN3O4

479.54

Scio-323 is an orally available p38 mitogen-activated protein kinase (MAPK) inhibitor with the potential to inhibit chronic inflammatory responses associated with polyethylene particles. Scio-323s oral inhibition pattern had a minimal effect on bone formation. Scio-323 administration inhibited net bone formation after the establishment of a chronic inflammatory response to polyethylene particles. Osteoblast-like activity remained low in all cases of Scio-323 inhibition. Scio-323 failed to improve bone growth in the presence of polyethylene particles [1] .

O=C(C1=CN(C)C2=C1C=C(C(N3CCC(CC3)CC4=CC=C(C=C4)F)=O)C(OC)=C2)C(N(C)C)=O

12352200