SCIO 469 hydrochloride

TargetMol Chemicals

SCIO 469 hydrochloride

999

Chemical

Research Use Only

SCIO 469 hydrochloride

Selective, ATP-competitive p38 inhibitor (IC50 = 9 nM for p38alpha in vitro). Displays approximately 10-fold selectivity for p38alpha over p38beta and 2000-fold selectivity for p38alpha over 20 other kinases. Reduces p38alpha phosphorylation in multiple myeloma cells in vitro and in vivo; activity results in decreased tumor burden and angiogenesis in murine models of multiple myeloma. Also enhances bortezomib-induced cytotoxicity against multiple myeloma cells.

3 years

-20°C

12352200