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ProductsBack/Sclerotiorin [549-23-5]
Chemical Structure
Chemical Structure
Chemical Structure

Sclerotiorin [549-23-5]

Research Use Only
AG-CN2-0054
AdipoGen Life Sciences
CAS Number549-23-5
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Product group Chemicals
Estimated Purity>97%
Molecular Weight390.9
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Sclerotiorin [549-23-5]
  • Delivery Days Customer
    10
  • CAS Number
    549-23-5
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Molecular Formula
    C21H23ClO5
  • Molecular Weight
    390.9
  • Scientific Description
    Antibiotic [4, 6, 7]. Antibacterial [4, 6, 7] with anticancer activity [8]. Weak antagonist of human endothelin receptor A (ETA) and B (ETB) [1]. Cholesteryl ester transfer protein (CETP) activity inhibitor [2]. Grb2-Shc binding inhibitor [3]. Potent aldose reductase inhibitor [4]. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor [5]. Antioxidant. Free radical scavenger [5]. Antifungal [6, 7]. - Chemical. CAS: 549-23-5. Formula: C21H23ClO5. MW: 390.9. Isolated from fungus Penicillium sp. Antibiotic. Antibacterial. Weak antagonist of human endothelin receptor A (ETA) and B (ETB). Cholesteryl ester transfer protein (CETP) activity inhibitor. Grb2-Shc binding inhibitor. Potent aldose reductase inhibitor. Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor. Antioxidant. Free radical scavenger. Antifungal.
  • SMILES
    CC[C@H](C)\C=C(/C)\C=C\C1=CC2=C(Cl)C(=O)[C@](C)(OC(C)=O)C(=O)C2=CO1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structure elucidation and biological activity: L. Pairet, et al.; J. Antibiot. (Tokyo) 48, 913 (1995)
  • Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones: H. Tomoda, et al.; J. Antibiot. (Tokyo) 52, 160 (1999)
  • Sclerotiorin and isochromophilone IV: Inhibitors of Grb2-Shc interaction, isolated from Penicillium multicolor F1753: N. Ji-Youn, et al.; J. Microbiol. Biotechnol. 10, 544 (2000)
  • Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase: C. Chidananda, et al.; Biotechnol. Lett. 28, 1633 (2006)
  • Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans: C. Chidananda & A.P. Sattur; J. Agric. Food. Chem. 55, 2879 (2007)
  • Antimicrobial properties of sclerotiorin, isocHromophilone VI and pencolide, metabolites from a Brazilian cerrado isolate of Penicillium sclerotiorum van Beyma: E. M.F. Lucas, et al.; Braz. J. Microbiol. 38, 785 (2007)
  • Synthesis and antifungal activity of novel sclerotiorin analogues: L. Lin, et al.; J. Agric. Food Chem. 60, 4480 (2012)