WB analysis of Daudi cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85173 SCUBE2 antibody. Working concentration : 1 microg/ml
WB analysis of Daudi cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85173 SCUBE2 antibody. Working concentration : 1 microg/ml
SCUBE2 antibody
GTX85173
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Rat
TargetSCUBE2
Overview
- SupplierGeneTex
- Product NameSCUBE2 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1 microg/mL. ICC/IF: 20 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID57758
- Target nameSCUBE2
- Target descriptionsignal peptide, CUB domain and EGF like domain containing 2
- Target synonymsCEGB1; CEGF1; CEGP1; scube/You; signal peptide, CUB and EGF-like domain-containing protein 2
- HostRabbit
- IsotypeIgG
- Protein IDQ9NQ36
- Protein NameSignal peptide, CUB and EGF-like domain-containing protein 2
- Scientific DescriptionSCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.
- ReactivityHuman, Rat
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Upregulated SCUBE2 expression in breast cancer stem cells enhances triple negative breast cancer aggression through modulation of notch signaling and epithelial-to-mesenchymal transition. Chen JH et al., 2018 Sep 15, Exp Cell ResRead more
- Inhibition of Endothelial SCUBE2 (Signal Peptide-CUB-EGF Domain-Containing Protein 2), a Novel VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) Coreceptor, Suppresses Tumor Angiogenesis. Lin YC et al., 2018 May, Arterioscler Thromb Vasc BiolRead more
- Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis. Lin YC et al., 2017 Jan, Arterioscler Thromb Vasc BiolRead more
- Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition. Lin YC et al., 2014 Jan 1, J Cell SciRead more