Proteins / Signaling Molecules

AdipoGen Life Sciences

Supplier

Research Use Only

Certification

P06804

Protein ID

Business Unit

AG-40B-0021 | TNF-alpha (mouse) (multimeric) (rec.) | AdipoGen Life Sciences available at Bio-Connect | Order online now!

TNF-alpha (mouse) (multimeri... | AG-40B-0021 | AdipoGen Life Sciences

TNF-alpha (mouse) (multimeric) (rec.)

Protein. The extracellular domain of mouse TNF-alpha (aa 77-235) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha™ can be used. - Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. MultimericTNF-alpha™ is a high activity construct in which two trimeric TNF-alpha ligands are artificially linked via the collagen domain of ACRP30. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (TNF-alpha (mouse) (multimeric) (rec.) (Prod. No. AG-40B-0021). Since the MultimericTNF-alpha™ mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal TNF-alpha or MultimericTNF-alpha™ can be used.

Website

Events

Promotions

Our company

Our team

For suppliers

Vacatures

About us

Headquarters

Customer Service

Technical support

Accountmanagers

Contact

Our people

Antibodies

Chemicals

Assays

(Cell) Culture

Products

Our Company

Suppliers

Divisions

News

Bio-Connect

Biotech, Pharma & CRO

Academia

Diagnostics

Environment

Food

Veterinary

Industries

Disclaimer

Privacy Statement

Terms and conditions

Are you looking for specific products, alternatives, documentation or need assistance with solving product related issues? Let our in-house technical support team help you.

We support your research

<p>For 15 years, we connect life science researchers specialized in the import and distribution of life science reagents from global suppliers.</p>

Support your research

DNA / RNA / Vectors

Cell Culture

Genome Editing and Engineering

Molecular Biology

Lysates / Extracts

Expression

Labware / Accesories

Body Products

Technique Specific Products

Arrays / Slides

Diagnostic

Biologicals

Life Sciences

Services

Become a partner

Call +31 (0)26 326 44 50

Search results: AG-40B-0021

Didn't find what you were looking for?