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SEC inhibitor KL-1 [900308-84-1]

SEC inhibitor KL-1 [900308-84-1]

Research Use Only
T16867
TargetMol Chemicals
CAS Number900308-84-1
Product group Chemicals
Molecular Weight345.78
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    SEC inhibitor KL-1
  • Delivery Days Customer
    4
  • CAS Number
    900308-84-1
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    SEC inhibitor KL-1
  • Molecular Formula
    C18H16ClNO4
  • Molecular Weight
    345.78
  • Scientific Description
    SEC inhibitor KL-1 (KL-1) is a potent, selective super elongation complex (SEC) inhibitor that exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 microM) and disrupts the interaction between the SEC scaffolding protein AFF4.
  • Shelf life instruction
    3 years
  • SMILES
    COc1cccc(c1)C(=O)\C=C(/O)C(=O)Nc1cc(Cl)ccc1C
  • Storage Instruction
    -20°C
  • UNSPSC
    51202000

References

  • Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy. Liang K et al., 2018 Oct 18, Cell
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