Secalonic acid F [60687-07-2]

Name: Secalonic acid F [60687-07-2]
SKU: AG-CN2-0488_A27
Availability: BackOrder

AG-CN2-0488

CAS Number60687-07-2

DownloadMSDS

Product group Chemicals

Estimated Purity>95%

Molecular Weight638.6

Product AG-CN2-0488 is not available

Product not available

There may be an alternative product available, please contact our technical support team.

More than 130 suppliers

ISO certified

In-house tech support

Overview

Supplier
AdipoGen Life Sciences
Product Name
Secalonic acid F [60687-07-2]
Delivery Days Customer
10
CAS Number
60687-07-2
Certification
Research Use Only
Estimated Purity
>95%
Hazard Information
Warning
Molecular Formula
C32H30O14
Molecular Weight
638.6
Scientific Description
Chemical. CAS: 60687-07-2. Formula: C32H30O14. MW: 638.6. Isolated from Penicillium oxalicum. Mycotoxin. Common contaminant in corn and other grains. Hybrid dimer of Blennolide A and B. Cytotoxic anticancer compound. Reported to induce apoptosis by modulating RhoGDI 2 levels in HL60 cells. Protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50=9.6microM). PTP1B is thought to function as a negative regulator of insulin and leptin signal transduction and therefore being involved in type 2 diabetes and obesity pathology. Antimicrobial agent against Bacillus megaterium. Allelopathic agent. - Mycotoxin. Common contaminant in corn and other grains. Hybrid dimer of Blennolide A and B. Cytotoxic anticancer compound. Reported to induce apoptosis by modulating RhoGDI 2 levels in HL60 cells. Protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50=9.6microM). PTP1B is thought to function as a negative regulator of insulin and leptin signal transduction and therefore being involved in type 2 diabetes and obesity pathology. Antimicrobial agent against Bacillus megaterium. Allelopathic agent.
SMILES
OC1=C2[C@](OC3=CC=C(C4=C(O)C(C(C5=C(O)C[C@H](C)[C@H](O)[C@]5(C(OC)=O)O6)=O)=C6C=C4)C(O)=C3C2=O)(C(OC)=O)[C@H](O)[C@@H](C)C1
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

References

Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus: R. Andersen, et al.; J. Org. Chem. 42, 352 (1977)
Cytostatic activity of naturally isolated isomers of secalonic acids and their chemically rearranged dimers: I. Kurobane, et al.; Drugs Exp. Clin. Res. 13, 339 (1987)
Physiological and biochemical mechanism of allelopathy of secalonic acid F on higher plants: R.S. Zeng, et al.; Agron. J. 93, 72 (2001)
Differential proteomic analysis of HL60 cells treated with secalonic acid F reveals caspase 3-induced cleavage of Rho GDP dissociation inhibitor 2: N. Li, et al.; Oncol. Rep. 28, 2016 (2012)
Asperdichrome, an unusual dimer of tetrahydroxanthone through an ether bond, with protein tyrosine phosphatase 1B inhibitory activity, from the Okinawan freshwater Aspergillus sp. TPU1343: H. Yamazaki, et al.; Tetrahed. Lett. 57, 732 (2016)